Tuesday, May 06, 2008, Rabi-us-Sani 29, 1429 A.H

 
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Hepatitis B – a real terror for Asia–Pacific Mom's diet may influence baby's sex
Sleep and strange bedfellows
Peculiar facts about shut-eye...

Health update
Heart disease warning for women

 

 


Hepatitis B – a real terror for Asia–Pacific

Hepatitis B is the most serious liver infection in the world and can lead to liver failure, cirrhosis (scarring) or caner. 80 percent of all liver cancer in the world is caused by chronic hepatitis B. Most people infected in adulthood are able to clear the Hepatitis B virus from their blood in six months. However, five percent to 10 percent of infected adults, 30 percent to 50 percent of infected children and 90 percent of infected babies cannot get rid of the Hepatitis B virus. These individuals with chronic Hepatitis Band are at increased danger of developing complications later in life.

These are the proceedings discussed at the 18th Annual Conference of the Asia-Pacific Association for the Study of the Liver (APASL) in Seoul, Korea. The Asia Pacific Association for he Study of the Liver was formed in August 1978 in Singapore. Since then, members have increased from 40 to nearly 5000.

Association covers the region from Manchuria in the North, to Australia in the South, to the Pacific Islands in the East and Iran in the West. The main objective of the association is to promote the scientific advancement and education of Hepatology in the Asia Pacific region, including the exchange of information and the development of consensus in the field of Hepatology. It coordinates scientific studies between scientists and clinicians living in this region and encourages the practice of medicine in liver diseases.

The Korean Association for the Study of the Liver was the exclusive host of the 18th Annual Conference of the Asian Pacific Association for the Study of the Liver in 2008. Approximately 2,000 medical practitioners specialising in the study of digestive disorders have attended the four-day conference. The APSAL meetings were focused on subjects related to the diagnosis and treatment of liver diseases and their regional epidemiology.

Experts suggested that Hepatitis B virus is 100 times more infectious than the AIDS virus. It is transmitted through contact with blood and body fluids. The main ways people become infected with Hepatitis B are:

• Perinatal (from mother to baby at birth).

• Child to child transmission

• Unsafe injections and transfusions.

• Sexual contact.

In most developing countries, almost all children infected with Hepatitis B obtain the virus via peri-natial or child to child contact. In many developed countries, the pattern of transmission is different and the majority of infections are acquired during young adulthood via sexual activity and by the use of drugs.

Following are the few alarming facts presented by the speakers at the event:

• 400 million people have chronic Hepatitis B in the world, 75 percent of them reside in Asia pacific region.

• 10 to 30 million people get Hepatitis B each year

• One million people die each year from Hepatitis B and its complications

• Two people die each minute from Hepatitis B and its complications

• China has the greatest burden of Hepatitis B and live cancer in the world. A third of the world's estimated Hepatitis B carriers are in China. Liver cancer is the third most common cancer in the China

• 360,000 people in East Asia (China, Hong Kong, Korea and Japan) die each year from chronic Hepatitis B and its complications

Asia Pacific region thus bears the greatest clinical, economic and social burden of chronic Hepatitis B that is the most alarming outcome of first phase of discussion. Now it is responsibility of the health policy makers, decision makers, health management consultants, clinicians and health care providers to establish an action plan to combat with that situation.

The second phase of discussion was mainly focused on management guidelines, as we are aware that there is no cure for chronic hepatitis B, therefore, the goal of chronic hepatitis B management is to eliminate or permanently suppress the replication of the hepatitis B virus to prevent progression of the disease, prolong survival and improve quality of the life. The more hepatitis B virus you have in your body (also known as viral load), the higher your chances of developing liver complications such s cirrhosis (scarring) and cancer.

Professor Ching-Lung Lai, Chief, Division of Gastroenterology and Hepatology University of Hong Kong said, "many chronic hepatitis B patients require long -term treatment. Unfortunately, the initial benefits of therapy can be lost after the development of resistance. The five-year entecavir data that demonstrate long-term minimal resistance at 1.2 percent can be of great importance for nucleoside-naive patients."

True to its sense - hepatitis B is an emerging threat to Pakistan health authorities and policy makers in general and to healthcare professionals in particular. Federal government has taken this uphill task of addressing this menace of hepatitis B through Prime Minister's programme for the prevention of hepatitis. This programme witnesses as good portion of fund to carryout various activities. Owing to the increased government efforts and a sincere handshake of private sectors, the situation seems to be getting better. The need of time is to get more focus towards the programme by involving the masses through a series of meaningful awareness campaigns. Coupled with the availability of newer therapies, optimism is prevailing that the out-bursting terror of hepatitis B shall be tackled effectively.

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Mom's diet may influence baby's sex

In the quest to select a baby's sex, success could depend on breakfast cereal and better nutrition, according to a new study that may offer some women another reason to eat their Wheaties.

Mothers-to-be who skip breakfast and eat less are more likely to give birth to girls, while moms who consume more calories and a wider range of nutrients - including, specifically, those from breakfast cereal - are more likely to deliver sons. That's according to new research by British scientists that provides what they say is the first-ever evidence that a mother's diet at conception may determine her baby's sex.

Researchers from the universities of Exeter and Oxford in England asked 740 first-time moms in the United Kingdom to keep food diaries before and during early pregnancy. The women didn't know the sex of their babies, but when researchers reviewed their food plans, they found that moms who consumed more calories of higher quality before conceiving were about 24 percent more likely to give birth to boys than moms who ate less.

"The overall sex ratio in our population was close to 50:50, but individual mothers had a greater chance of bearing male offspring if their nutrient intake was high prior to conception," wrote Fiona Mathews, the study's lead author and a research fellow at the University of Exeter. "The consumption of breakfast cereal was also strongly associated with having a male infant."

Fifty-six percent of women in the group with the highest energy intake gave birth to boys, compared to 45 percent in the group with the lowest energy consumption, according to the study.

Mothers of boys consumed an average of 2,413 calories a day before conception and higher amounts of foods containing potassium, calcium and vitamins C, E and B12, the researchers said. Women who had girls logged 2,283 calories a day and less protein, vitamins and minerals.

Odds of having a boy were much higher for women who ate at least one bowl of breakfast cereal a day compared to women who ate less than one bowl a week, the study said. Breakfast cereals are usually fortified by vitamins and minerals.

Critics wary of claims

Critics, however, said the new research contradicts basic facts of human genetics. A father's sperm determines a child's sex, and there's no evidence that maternal nutrition has anything to do with it, said Dr Paul Magarelli, Vice President, Pacific Coast Reproductive Society.

"A correlation does not make the truth," said Magarelli, who is also director of the Reproductive Medicine and Fertility Centre in Colorado Springs, Colo. "I think it's a spurious correlation, that's all I can say."

The British scientists said that although fathers do determine sex, their research indicates that mothers' may be able to favour the development of one sex over another, perhaps in the way that high-glucose environments in in-vitro fertilisation appear to favour male embryos and inhibit female embryos.

The research is also supported by an evolutionary drive to produce more offspring in times of plenty. In many animals - including horses, cows and some species of deer - more males are produced when a mother has more resources, the scientists noted.

Skipping breakfast, for instance, extends overnight fasting and depresses glucose levels, which could be interpreted by the body as a poor environment, researchers said.

Their argument deserves further study, said Dr Tarun Jain, an assistant professor of reproductive endocrinology at the University of Illinois at Chicago. "It's not showing far and away that if women eat a certain diet they'll have a boy or a girl, but it certainly is giving us some information," Jain said. "Could there be dietary factors that influence conception?"

Diet trends may explain fewer boys.

In addition to suggesting that breakfast cereal may produce more boys, the researchers said that nutrition and diet trends may account for an incremental decline in male births in developing nations. Over the last 40 years, births of boys have also dropped by about one per 1000 births annually in the United States, the U.K. and Canada, they said.

At the same time, many young women in those developed nations have begun skipping breakfast and eating poorer-quality diets.

"This research may help explain why, in developed countries, where many young women choose to have low-calorie diets, the proportion of boys born is falling," Mathews said.

That's counter to the trend in countries such as India, Vietnam and China, where births of boys now outpace girls because parents selective sex techniques, including abortion, to obtain highly prized sons.

The new study may influence mothers to try to use nutrition to select sex, which worries ethicists such as Nigel Cameron, president of the Institute on Biotechnology and the Human Future at the Chicago-Kent College of Law at the Illinois Institute of Technology.

"It adds to the manipulative tool box whose purpose is designer babies. We need a lot more social debate about the fact that children should be received as-is," said Cameron.

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Sleep and strange bedfellows
Peculiar facts about shut-eye...

What really happens when your head hits the pillow? Sure, sleep fulfills some very basic needs-like maintaining your physical and mental health, not to mention preparing you for those crucial daytime hours. But a lot more happens after the lights go out. Did you know that sleep affects your memory, your heart, and even the health of your teeth? Here, we unveil some of sleep's strangest facts.

Flexing memory

From a special vacation to a holiday gathering, long-term memories are predominantly formed during sleep when the brain replays recent experiences. But how do you remember what happens when? According to researchers at the University of Lubeck in Germany, shut-eye not only strengthens a memory's content but also the sequence in which they are experienced. Students were presented sets of words in a particular order. One group of these students was allowed to sleep and another was not. Those who were allowed to sleep could more often recall the order of words than those who were not allowed to sleep.

Sleep to a better beat

A good night's sleep is essential for a healthy ticker. Lack of sleep can lead to hypertension, a condition in which blood pressure is chronically elevated. Of course, with it comes a higher risk of heart attack or stroke. Even normal, healthy people, who are persistently deprived of proper sleep, suffer increased risk of hypertension, say researchers at the American Academy of Sleep Medicine. Ongoing sleep deprivation can set up chemical and hormonal changes in the body, including the release of stress hormones like adrenaline.

Snooze and Smile

Tossing and turning can affect your smile. A study shows that the amount of sleep you get can significantly affect your teeth. While smoking negatively impacted oral health the most, hours of sleep closely followed. The study tracked 219 Japanese factory workers from 1999 through 2003. Participants who slept seven to eight hours a night had less periodontal disease than those who slept six hours or less a night. Researchers speculate that sleep shortage impairs the body's immune system, something that can lead to bad teeth.

Sleep to your own rhythm

If you find yourself awake and energetic late at night, you may have a genetic mutation. The altered gene may explain why some people prefer late nights. This gene affects the body's circadian cycle-the clock that keeps our metabolism, digestion, and sleep patterns in sync. Researchers discovered abnormally long circadian rhythms in some mice-lasting about 27 hours instead of the normal cycle of 24 hours. These mice had the mutated gene. Also, night owls who compensate by staying in bed longer still experience more insomnia than the rest of us. Also, night owls report feeling less in control of their sleep, which may also fuel insomnia.

Getting by with less

Some people can survive on very little sleep, while others require many hours to function normally. If you still perform relatively well when sleep deprived, the reason could be your genes. In one study from the University of Surrey, some people struggled to stay awake after two days of no sleep while others had no problem whatsoever. The researchers looked into this further and gave the participants the opportunity to sleep normally; they found that some participants spend more time in slow-wave sleep, the deepest form of shut-eye. And for them carrying a sleep debt makes it that much harder to stay alert and function.

--www.msn.com



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Health update

Heart disease warning for women

Fears are being raised that rising levels of obesity and diabetes may be affecting the fall in heart disease death rates in women aged under 50. Researchers from Oxford and Manchester universities studied all deaths in England and Wales from 1931 to 2005 and found the pace of the drop had started to slow. Heart disease death rates for all age groups increased until the 1970s, but have been falling continuously since. This has been put down to better treatment and a fall in the number of people smoking. Report author Peter Scarborough said, "What we may be seeing with the figures for women is a plateauing and in the future it may even rise.

 

Gene therapy improves vision in nearly blind

Scientists for the first time have used gene therapy to dramatically improve sight in people with a rare form of blindness. Experts called this development a major advancement for the experimental technique. Some vision was restored in four of the six young people who got the treatment, teams of researchers in the United States and Britain reported. Two of the volunteers who could only see hand motions were able to read a few lines of an eye chart within weeks. The two teams of scientists, working separately, each tested gene replacement therapy in three patients with a form of a rare hereditary eye disease called Leber's congenital amaurosis.

 

Memory training can improve problem solving and intelligence

Brain-training efforts designed to improve working memory can also boost scores in general problem-solving ability and improve fluid intelligence, according to new University of Michigan research. "Considering the fundamental importance of fluid intelligence in everyday life and its predictive power for a large variety of intellectual tasks and professional success, we believe that our findings may be highly relevant to applications in education," U-M psychology researchers Susanne Jaeggi and Martin Buschkuehl concluded. Many psychologists believe general intelligence can be separated into "fluid" and "crystalline" components. Fluid intelligence, considered one of the most important factors in learning, applies to all problems while crystallised intelligence consists of skills useful for specific tasks. 

 

Chocoholics wanted for new study

British researchers are recruiting volunteers willing to eat a bar of chocolate daily for a year, guilt-free and all in the name of science. The trial starting in June will explore whether compounds called flavonoids found in chocolate and other foods can reduce the risk of heart disease for menopausal women with type 2 diabetes, the researchers said. "We are looking at a high risk group first," said Aedin Cassidy, a biochemist at the University of East Anglia, who will lead the study. "We hope there will be an additional benefit from dietary intervention in addition to the women's drug therapy." Previous studies have suggested dark chocolate is rich in the beneficial compounds linked with heart health but experts note the high sugar and fat content of most commercially available chocolate might cancel out some of the advantages.



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